N-Iodosuccinimide → HCID 58513333, compound

HRID 1405026Notes

Reaction equation

[C:1]([O:5][C:6](=[O:26])[NH:7][C:8]1[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:11]=[C:10]([C:18]2[CH:23]=[C:22]([CH3:24])[N:21]=[C:20]([NH2:25])[N:19]=2)[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].C1C(=O)N([I:34])C(=O)C1>>[C:1]([O:5][C:6](=[O:26])[NH:7][C:8]1[CH:13]=[C:12]([C:14]([F:16])([F:17])[F:15])[CH:11]=[C:10]([C:18]2[C:23]([I:34])=[C:22]([CH3:24])[N:21]=[C:20]([NH2:25])[N:19]=2)[CH:9]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 120273N-Iodosuccinimide

HCID 58513337HCID 58513337, compound

Product 1

HCID 58513333HCID 58513333, compound

Procedure

The title compound is synthesized according to general procedure GP1 starting from 550 mg (1.5 mmol) [3-(2-amino-6-methyl-pyrimidin-4-yl)-5-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (GP40) and 336 mg (1.5 mmol) NIS. Yield: 733 mg (99%).

Sources & evidence

ORD record: ord-692c3bfbd9104f768a3ae3f676e6376c
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08916548B2

Reaction notes

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