2,4-Diamino-6-chloropyrimidine → HCID 58513369, compound

HRID 1405031Notes

Reaction equation

HRID 1405031 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([NH2:8])[N:5]=[C:4]([NH2:9])[CH:3]=1.C1C(=O)N([I:17])C(=O)C1>>[Cl:1][C:2]1[N:7]=[C:6]([NH2:8])[N:5]=[C:4]([NH2:9])[C:3]=1[I:17]

Participants

3

Reactant 2

HCID 674322,4-Diamino-6-chloropyrimidineHCID 120273N-Iodosuccinimide

Product 1

HCID 58513369HCID 58513369, compound

Procedure

The title compound is synthesized according to general procedure GP1 starting from 25 g (173 mmol) 6-chloro-pyrimidine-2,4-diamine and 39 g (173 mmol) NIS. Yield after precipitation of the product from water: 38.8 g (83%).

Workup

  1. customYield
  2. customafter precipitation of the product from water

Sources & evidence

ORD record
ord-0718e0cf32f34afc8c777b6a9e0108b1
Source dataset
uspto-grants-2014_12
Patent number
US08916548B2

Reaction notes

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