HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 58513433, compound → HCID 58513111, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 58513433 | HCID 58513433 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 58513111 | HCID 58513111 | — |
Reaction Steps
The title compound is synthesized according to general procedure GP8 starting from 630 mg (1.6 mmol) 4-[2-amino-5-(6-amino-pyridin-3-ylethynyl)-6-ethyl-pyrimidin-4-yl]-2-fluoro-benzoic acid methyl ester using 1.6 mL (1.6 mmol) 1 N NaOH in 10 mL THF. The precipitate is collected by filtration and washed with THF. Yield: 580 mg (96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916548B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-690a1eb3831e4e129f1c0a96520fae71 |
| Source note | uspto-grants-2014_12 |