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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1405042Generated: November 2, 2026

HCID 58513433, compound → HCID 58513111, compound

https://huagongshe.com/reaction/1405042

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 58513433HCID 58513433—
SolventTetrahydrofuranHCID 8028—
ProductHCID 58513111HCID 58513111—

Reaction Steps

The title compound is synthesized according to general procedure GP8 starting from 630 mg (1.6 mmol) 4-[2-amino-5-(6-amino-pyridin-3-ylethynyl)-6-ethyl-pyrimidin-4-yl]-2-fluoro-benzoic acid methyl ester using 1.6 mL (1.6 mmol) 1 N NaOH in 10 mL THF. The precipitate is collected by filtration and washed with THF. Yield: 580 mg (96%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08916548B2
Source datasetuspto-grants-2014_12
ORD IDord-690a1eb3831e4e129f1c0a96520fae71
Source noteuspto-grants-2014_12