HCID 58513278, compound → HCID 58513287, compound

Participants

Reaction Steps

The title compound is synthesized according to general procedure GP8 starting from 951 mg (2.3 mmol) 4-[2-amino-5-(6-amino-pyridin-3-ylethynyl)-6-ethyl-pyrimidin-4-yl]-2-chloro-benzoic acid methyl ester using 3.5 mL (3.5 mmol) 1 N NaOH in 16 mL THF. The product precipitates from the reaction mixture and is isolated by filtration. The product is washed with THF and diethylether. Yield: 345 mg (38%).

Provenance & Evidence