HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 58513462, compound → HCID 58513316, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 58513462 | HCID 58513462 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 58513316 | HCID 58513316 | — |
Reaction Steps
The title compound is synthesized according to general procedure GP8 starting from 3.0 g (8.0 mmol) 4-[2-amino-5-(6-amino-pyridin-3-ylethynyl)-6-methyl-pyrimidin-4-yl]-2-fluorobenzoic acid methyl ester using 12 mL (12 mmol) 1 N NaOH in 30 mL THF. The product precipitates and is isolated by filtration. The product is washed with water. Yield: 2.2 g (76%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916548B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-249c1714240a44e4ab1336d401c3bcac |
| Source note | uspto-grants-2014_12 |