HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromoisoquinoline → tert-Butyl 4-(isoquinolin-4-yl)phenylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromoisoquinoline | HCID 73743 | — |
| Reactant | (4-Boc-Aminophenyl)Boronic Acid | HCID 3613184 | — |
| Reactant | 4-(4-methylpyridin-3-yl)-1H-indazole | HCID 66715654 | — |
| Product | tert-Butyl 4-(isoquinolin-4-yl)phenylcarbamate | HCID 68086489 | — |
Reaction Steps
Intermediate 10A was prepared from 4-bromoisoquinoline and 4-(tert-butoxy carbonylamino)phenylboronic acid by the procedure described for the preparation of Intermediate 1C, and was obtained as an off-white foam (63% yield). MS (ES): m/z=321.2 [M+H]+. HPLC Ret timea: 2.432 min. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.51 (s, 9 H) 7.44 (d, J=8.53 Hz, 2 H) 7.65 (d, J=8.53 Hz, 2 H) 7.68-7.75 (m, 1 H) 7.75-7.82 (m, 1 H) 7.88 (d, J=8.53 Hz, 1 H) 8.20 (d, J=7.78 Hz, 1 H) 8.40 (s, 1 H) 9.31 (s, 1 H) 9.57 (s, 1 H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916553B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-0ab912ddae0041caacc8493fad93e1a9 |
| Source note | uspto-grants-2014_12 |