反应详情

To a solution of Intermediate 13B in MeOH (3 mL) was added Pd/C (33.2 mg, 0.031 mmol). The resulting mixture was stirred under H2 atmosphere for 2 hours and then filtered through a pad of CELITE®/silica. The filtrate was concentrated to yield the Intermediate 13 (100 mg, 0.406 mmol, 78% yield). MS (ES): m/z=247.0 [M+H]+. Intermediate 13 was used in the synthesis of the compounds of Examples 8 and 9.

1. filtrationfiltered through a pad of CELITE®/silica
2. concentrationThe filtrate was concentrated