HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Cyano-3,3-bis(methylthio)acrylamide → 2-Cyano-3-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)-3-(methylthio)acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Cyano-3,3-bis(methylthio)acrylamide | HCID 2747746 | — |
| Reactant | 4-[4-(Propan-2-yl)piperazin-1-yl]aniline | HCID 9161545 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Cyano-3-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)-3-(methylthio)acrylamide | HCID 86701874 | — |
Reaction Steps
Dissolved 0.500 g 2-cyano-3,3-bis(methylthio)acrylamide in 15 mL EtOH and added 4-(4-(2-propyl)-piperazin-1-yl)aniline (1.0 eq.). Stirred reaction at 75° C. until starting amide was absent by HPLC. Once complete (18 hrs), reaction was brought to room temperature and filtered to obtain 2-cyano-3-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)-3-(methylthio)acrylamide as a purple powder. Product was allowed to dry under vacuum for 1 hr.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916555B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-e086d0f19cc3497fbb1ef83e0b28dcb3 |
| Source note | uspto-grants-2014_12 |