HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1405108Generated: October 26, 2026
Hydrazine hydrate (1:1) → 5-amino-3-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)-1H-pyrazole-4-carboxamide
https://huagongshe.com/reaction/1405108
Participants
| Role | Name | HCID | Charge |
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| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2-Cyano-3-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)-3-(methylthio)acrylamide | HCID 86701874 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-amino-3-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)-1H-pyrazole-4-carboxamide | HCID 86701873 | — |
Reaction Steps
2-cyano-3-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)-3-(methylthio)acrylamide was then suspended in 10 mL EtOH and hydrazine hydrate (1 eq.) was added dropwise. Reaction was heated at 75° C. until intermediate was absent (HPLC). Once intermediate was absent (18 hrs), reaction was brought to room temperature and filtered to obtain 5-amino-3-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)-1H-pyrazole-4-carboxamide as a purple powder. Product was allowed to dry under vacuum for 1 hr.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08916555B2 |
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| Source dataset | uspto-grants-2014_12 |
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| ORD ID | ord-211ab0bbd7ff42a1977de07e713a7559 |
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| Source note | uspto-grants-2014_12 |
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