Ethanol → HCID 86701888, compound

Participants

Reaction Conditions

Reaction Steps

3-([1,1′-biphenyl]-3-ylamino)-2-cyano-3-(methylthio)acrylamide was then suspended in 10 mL EtOH and hydrazine hydrate (124 μL, 1.0 eq.) was added dropwise. Reaction was heated at 75° C. until intermediate was absent (HPLC). Once intermediate was absent (18 hrs), reaction was brought to room temperature and filtered to obtain 3-([1,1′-biphenyl]-4-ylamino)-5-amino-1H-pyrazole-4-carboxamide as a yellow powder. Product was allowed to dry under vacuum for 1 hr.

Provenance & Evidence