HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2,2-Difluoro-1,3-dioxaindan-4-yl)boronic acid → 4-(2,2-Difluoro-1,3-benzodioxol-4-yl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2,2-Difluoro-1,3-dioxaindan-4-yl)boronic acid | HCID 16427145 | — |
| Reactant | 4-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine | HCID 21956343 | — |
| Product | 4-(2,2-Difluoro-1,3-benzodioxol-4-yl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine | HCID 66576281 | — |
Reaction Steps
Example 6 was prepared under similar conditions as described in the preparation of Example 1 using crude 4-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine and (2,2-difluoro-1,3-benzodioxol-4-yl)boronic acid (Aalen Chemical Co., Ltd.). The batch was purified by preparative HPLC:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916557B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-1c455b11701348ff80af0d8c8269e314 |
| Source note | uspto-grants-2014_12 |