4-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine → HCID 66576359, compound

HRID 1405182Notes

Reaction equation

HRID 1405182 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:10]=2)[N:3]=1.CC1(C)C(C)(C)OB([C:28]2[C:36]3[O:35][CH2:34][CH2:33][C:32]=3[CH:31]=[CH:30][CH:29]=2)O1>>[O:35]1[C:36]2[C:28]([C:2]3[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]4[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:10]=4)[N:3]=3)=[CH:29][CH:30]=[CH:31][C:32]=2[CH2:33][CH2:34]1

Participants

3

Reactant 2

HCID 219563434-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amineHCID 438110277-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1-benzofuran

Product 1

HCID 66576359HCID 66576359, compound

Procedure

Example 13 was prepared under similar conditions as described in the preparation of Example 1 using crude 4-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine and 7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1-benzofuran (ChemBridge Corporation). The batch was purified by preparative HPLC:

Workup

  1. customExample 13 was prepared under similar conditions
  2. customThe batch was purified by preparative HPLC

Sources & evidence

ORD record
ord-664df22c9ff340dbbe0fa57afce621d4
Source dataset
uspto-grants-2014_12
Patent number
US08916557B2

Reaction notes

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