4-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine → HCID 70977703, compound

HRID 1405185Notes

Reaction equation

HRID 1405185 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:10]=2)[N:3]=1.[F:20][C:21]([F:34])([F:33])[CH2:22][O:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1B(O)O>>[CH3:19][S:16]([CH2:15][C:11]1[CH:10]=[C:9]([NH:8][C:4]2[N:3]=[C:2]([C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=3[O:23][CH2:22][C:21]([F:20])([F:34])[F:33])[N:7]=[CH:6][N:5]=2)[CH:14]=[CH:13][CH:12]=1)(=[O:18])=[O:17]

Participants

3

Reactant 2

HCID 219563434-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amineHCID 43145273[2-(2,2,2-Trifluoroethoxy)phenyl]boronic acid

Product 1

HCID 70977703HCID 70977703, compound

Procedure

Example 16 was prepared under similar conditions as described in the preparation of Example 1 using crude 4-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine and [2-(2,2,2-trifluoroethoxy)phenyl]boronic acid (Combi-Blocks Inc.). The batch was purified by preparative HPLC:

Workup

  1. customExample 16 was prepared under similar conditions
  2. customThe batch was purified by preparative HPLC

Sources & evidence

ORD record
ord-79ffb7f41c004d85a36a88d427513951
Source dataset
uspto-grants-2014_12
Patent number
US08916557B2

Reaction notes

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