2,3-Dihydro-1,4-benzodioxin-5-ylboronic acid → HCID 66576432, compound

HRID 1405186Notes

Reaction equation

HRID 1405186 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:10]=2)[N:3]=1.[O:20]1[C:25]2[CH:26]=[CH:27][CH:28]=[C:29](B(O)O)[C:24]=2[O:23][CH2:22][CH2:21]1>>[O:20]1[C:25]2[CH:26]=[CH:27][CH:28]=[C:29]([C:2]3[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]4[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:10]=4)[N:3]=3)[C:24]=2[O:23][CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 46831952,3-Dihydro-1,4-benzodioxin-5-ylboronic acidHCID 219563434-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine

Product 1

HCID 66576432HCID 66576432, compound

Procedure

Example 18 was prepared under similar conditions as described in the preparation of Example 1 using crude 4-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine and 2,3-dihydro-1,4-benzodioxin-5-ylboronic acid (Combi-Blocks Inc.). The batch was purified by preparative HPLC.

Workup

  1. customExample 18 was prepared under similar conditions
  2. customThe batch was purified by preparative HPLC

Sources & evidence

ORD record
ord-1244fdc8e4ff43e1ab58911cced7b124
Source dataset
uspto-grants-2014_12
Patent number
US08916557B2

Reaction notes

Loading…