2,4-Dichloro-1,3,5-triazine → HCID 89155990, compound

Participants

Reaction Steps

To a stirred solution of 2,4-dichloro-1,3,5-triazine (150 mg, ABCR GmbH & CO. KG) in THF/i-PrOH (1:1; 1.9 mL) DIPEA (0.35 mL) was added at −40° C. Then a suspension of 3-[(cyclopentylsulfonyl)methyl]aniline (240 mg) in THF/2-PrOH (1:1, 0.94 mL) was added at this temperature. Under stirring the temperature of the reaction mixture was slowly raised over 2 hours to 0° C. The reaction mixture was then concentrated in vacuo to give the crude title compound (726 mg) which was used without further purification.

Provenance & Evidence