HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoro-2-(3-fluorophenylmethoxy)phenylboronic acid → 4-{5-Fluoro-2-[(3-fluorobenzyl)oxy]phenyl}-N-{3-[(prop-2-ylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoro-2-(3-fluorophenylmethoxy)phenylboronic acid | HCID 43327941 | — |
| Reactant | 4-Chloro-N-{3-[(propan-2-ylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine | HCID 89155955 | — |
| Product | 4-{5-Fluoro-2-[(3-fluorobenzyl)oxy]phenyl}-N-{3-[(prop-2-ylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine | HCID 66576677 | — |
Reaction Steps
A suspension of crude 4-chloro-N-{3-[(prop-2-ylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine (876 mg, 37% by weight) and {5-fluoro-2-[(3-fluorobenzyl)oxy]phenyl}boronic acid (264 mg) was treated as described in example 34. One obtained pure product (299 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916557B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-2f9538e6bc6f4a1ea83a0e40d25cca79 |
| Source note | uspto-grants-2014_12 |