Cyclopentaneethanol → HCID 66576914, compound

HRID 1405223Notes

Reaction equation

HRID 1405223 reaction equation
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=2)[N:10]=1.[CH:27]1([CH2:32][CH2:33][OH:34])[CH2:31][CH2:30][CH2:29][CH2:28]1>>[CH:27]1([CH2:32][CH2:33][O:34][C:2]2[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=2[C:9]2[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=3)[N:10]=2)[CH2:31][CH2:30][CH2:29][CH2:28]1

Participants

3

Reactant 2

HCID 69833CyclopentaneethanolHCID 709765244-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine

Product 1

HCID 66576914HCID 66576914, compound

Procedure

Starting with 4-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine (75 mg; 0.197 mmol), intermediate 42.1, and 2-cyclopentylethanol (101 μl; 0.789 mmol), example 53 was prepared analogously to the procedure for the preparation of example 42.

Workup

  1. customwas prepared analogously to the procedure for the preparation of example 42

Sources & evidence

ORD record
ord-d6f6bc165f1f47e782b38606bb61103a
Source dataset
uspto-grants-2014_12
Patent number
US08916557B2

Reaction notes

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