4,4,4-Trifluorobutan-1-ol → HCID 66575731, compound

HRID 1405229Notes

Reaction equation

HRID 1405229 reaction equation
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=2)[N:10]=1.[F:27][C:28]([F:34])([F:33])[CH2:29][CH2:30][CH2:31][OH:32]>>[F:8][C:6]1[CH:5]=[CH:4][C:3]([C:9]2[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=3)[N:10]=2)=[C:2]([O:32][CH2:31][CH2:30][CH2:29][C:28]([F:34])([F:33])[F:27])[CH:7]=1

Participants

3

Reactant 2

HCID 1363074,4,4-Trifluorobutan-1-olHCID 709765244-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine

Product 1

HCID 66575731HCID 66575731, compound

Procedure

Starting with 4-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine (70 mg; 0.184 mmol), intermediate 42.1, and 4,4,4-trifluorobutan-1-ol (94.3 mg; 0.736 mmol), example 59 was prepared analogously to the procedure for the preparation of example 42.

Workup

  1. customwas prepared analogously to the procedure for the preparation of example 42

Sources & evidence

ORD record
ord-559c28e0087c48f6ac287b3ad476b3f7
Source dataset
uspto-grants-2014_12
Patent number
US08916557B2

Reaction notes

Loading…