2-Cyclohexylethanol → HCID 66575735, compound

HRID 1405233Notes

Reaction equation

HRID 1405233 reaction equation
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=2)[N:10]=1.[CH:27]1([CH2:33][CH2:34][OH:35])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1>>[CH:27]1([CH2:33][CH2:34][O:35][C:2]2[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=2[C:9]2[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=3)[N:10]=2)[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1

Participants

3

Reactant 2

HCID 205082-CyclohexylethanolHCID 709765244-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine

Product 1

HCID 66575735HCID 66575735, compound

Procedure

Starting with 4-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine (75 mg; 0.197 mmol), intermediate 42.1, and 2-cyclohexylethanol (111 μl; 0.789 mmol), example 63 was prepared analogously to the procedure for the preparation of example 43.

Workup

  1. customwas prepared analogously to the procedure for the preparation of example 43

Sources & evidence

ORD record
ord-8d7e1f559d4c4e09b6e2c2d437e6f377
Source dataset
uspto-grants-2014_12
Patent number
US08916557B2

Reaction notes

Loading…