(1-Fluorocyclohexyl)methanol → HCID 66575808, compound

HRID 1405236Notes

Reaction equation

HRID 1405236 reaction equation
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=2)[N:10]=1.[F:27][C:28]1([CH2:34][OH:35])[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1>>[F:8][C:6]1[CH:5]=[CH:4][C:3]([C:9]2[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=3)[N:10]=2)=[C:2]([O:35][CH2:34][C:28]2([F:27])[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)[CH:7]=1

Participants

3

Reactant 2

HCID 18342450(1-Fluorocyclohexyl)methanolHCID 709765244-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine

Product 1

HCID 66575808HCID 66575808, compound

Procedure

Starting with 4-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine (80 mg; 0.21 mmol), intermediate 42.1, and (1-fluorocyclohexyl)methanol (117 mg; 0.841 mmol), example 66 was prepared analogously to the procedure for the preparation of example 42.

Workup

  1. customwas prepared analogously to the procedure for the preparation of example 42

Sources & evidence

ORD record
ord-18176697949843d79671e978787a6866
Source dataset
uspto-grants-2014_12
Patent number
US08916557B2

Reaction notes

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