1-Phenylethanol → HCID 66575810, compound

HRID 1405238Notes

Reaction equation

HRID 1405238 reaction equation
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=2)[N:10]=1.[CH3:27][CH:28]([OH:35])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[F:8][C:6]1[CH:5]=[CH:4][C:3]([C:9]2[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=3)[N:10]=2)=[C:2]([O:35][CH:28]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH3:27])[CH:7]=1

Participants

3

Reactant 2

HCID 74091-PhenylethanolHCID 709765244-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine

Product 1

HCID 66575810HCID 66575810, compound

Procedure

Starting with 4-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine (50 mg; 0.129 mmol), intermediate 42.1, and DL-1-phenylethanol (63 mg; 0.515 mmol), example 68 was prepared analogously to the procedure for the preparation of example 42.

Workup

  1. customwas prepared analogously to the procedure for the preparation of example 42

Sources & evidence

ORD record
ord-07f7816caa564228b1b6028b0fb3fc6c
Source dataset
uspto-grants-2014_12
Patent number
US08916557B2

Reaction notes

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