(2,3,4-Trifluorophenyl)methanol → HCID 66575892, compound

HRID 1405242Notes

Reaction equation

HRID 1405242 reaction equation
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=2)[N:10]=1.[F:27][C:28]1[C:35]([F:36])=[C:34]([F:37])[CH:33]=[CH:32][C:29]=1[CH2:30][OH:31]>>[F:8][C:6]1[CH:5]=[CH:4][C:3]([C:9]2[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=3)[N:10]=2)=[C:2]([O:31][CH2:30][C:29]2[CH:32]=[CH:33][C:34]([F:37])=[C:35]([F:36])[C:28]=2[F:27])[CH:7]=1

Participants

3

Reactant 2

HCID 2777027(2,3,4-Trifluorophenyl)methanolHCID 709765244-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine

Product 1

HCID 66575892HCID 66575892, compound

Procedure

Starting with 4-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine (70 mg; 0.184 mmol), intermediate 42.1, and 2,3,4-trifluorobenzyl alcohol (119 mg; 0.736 mmol), example 72 was prepared analogously to the procedure for the preparation of example 42.

Workup

  1. customwas prepared analogously to the procedure for the preparation of example 42

Sources & evidence

ORD record
ord-d0e912dc182c427a8da41a04c675662c
Source dataset
uspto-grants-2014_12
Patent number
US08916557B2

Reaction notes

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