4-(Trifluoromethyl)benzenemethanol → HCID 66575893, compound

HRID 1405243Notes

Reaction equation

HRID 1405243 reaction equation
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=2)[N:10]=1.[F:27][C:28]([F:38])([F:37])[C:29]1[CH:36]=[CH:35][C:32]([CH2:33][OH:34])=[CH:31][CH:30]=1>>[F:8][C:6]1[CH:5]=[CH:4][C:3]([C:9]2[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=3)[N:10]=2)=[C:2]([O:34][CH2:33][C:32]2[CH:31]=[CH:30][C:29]([C:28]([F:27])([F:37])[F:38])=[CH:36][CH:35]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 676844-(Trifluoromethyl)benzenemethanolHCID 709765244-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine

Product 1

HCID 66575893HCID 66575893, compound

Procedure

Starting with 4-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine (70 mg; 0.184 mmol), intermediate 42.1, and 4-(trifluoromethyl)benzyl alcohol (132 mg; 0.736 mmol), example 73 was prepared analogously to the procedure for the preparation of example 42.

Workup

  1. customwas prepared analogously to the procedure for the preparation of example 42

Sources & evidence

ORD record
ord-472f97c360554811b603ad4c93cbb827
Source dataset
uspto-grants-2014_12
Patent number
US08916557B2

Reaction notes

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