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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1405245Generated: November 1, 2026

2,4,5-Trifluorobenzyl Alcohol → 4-{4-Fluoro-2-[(2,4,5-trifluorobenzyl)oxy]phenyl}-N-{3-[(methylsulfonyl)-methyl]phenyl}-1,3,5-triazin-2-amine

https://huagongshe.com/reaction/1405245

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,4,5-Trifluorobenzyl AlcoholHCID 2777035—
Reactant4-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amineHCID 70976524—
Product4-{4-Fluoro-2-[(2,4,5-trifluorobenzyl)oxy]phenyl}-N-{3-[(methylsulfonyl)-methyl]phenyl}-1,3,5-triazin-2-amineHCID 66575973—

Reaction Steps

Starting with 4-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine (70 mg; 0.184 mmol), intermediate 42.1, and 2,4,5-trifluorobenzyl alcohol (123 mg; 0.736 mmol), example 75 was prepared analogously to the procedure for the preparation of example 42.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08916557B2
Source datasetuspto-grants-2014_12
ORD IDord-b2e573c8944547c8a4a847423d707e32
Source noteuspto-grants-2014_12