2,3-Difluorobenzyl Alcohol → 4-{2-[(2,3-Difluorobenzyl)oxy]-4-fluorophenyl}-N-{3-[(methylsulfonyl)-methyl]phenyl}-1,3,5-triazin-2-amine

HRID 1405249Notes

Reaction equation

HRID 1405249 reaction equation
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=2)[N:10]=1.[F:27][C:28]1[C:35]([F:36])=[CH:34][CH:33]=[CH:32][C:29]=1[CH2:30][OH:31]>>[F:27][C:28]1[C:35]([F:36])=[CH:34][CH:33]=[CH:32][C:29]=1[CH2:30][O:31][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=2)[N:10]=1

Participants

3

Reactant 2

HCID 4471532,3-Difluorobenzyl AlcoholHCID 709765244-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine

Product 1

HCID 665760524-{2-[(2,3-Difluorobenzyl)oxy]-4-fluorophenyl}-N-{3-[(methylsulfonyl)-methyl]phenyl}-1,3,5-triazin-2-amine

Procedure

Starting with 4-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine (70 mg; 0.184 mmol), intermediate 42.1, and 2,3-difluorobenzyl alcohol (113 mg; 0.736 mmol), example 80 was prepared analogously to the procedure for the preparation of example 42.

Workup

  1. customwas prepared analogously to the procedure for the preparation of example 42

Sources & evidence

ORD record
ord-ea9ea69c05734fb784567f6e6e95d1b6
Source dataset
uspto-grants-2014_12
Patent number
US08916557B2

Reaction notes

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