Sodium Hydroxide → 3-[methyl(propan-2-yl)amino]-2-(2-methyl-1H-indol-5-yl)quinoxaline-6-carboxylic acid

Participants

Reaction Steps

To a solution of methyl 3-[methyl(propan-2-yl)amino]-2-(2-methyl-1H-indol-5-yl)quinoxaline-6-carboxylate (660 mg, 1.70 mmol) in methanol (40 ml) was added a solution of NaOH (340 mg, 8.50 mmol) in water (5 ml). The resulting solution was stirred overnight at room temperature and then concentrated in vacuo. The residue was dissolved in water (20 ml), adjusted to pH 4 with HCl (3N). The product was precipitated from water and collected by filtration to afford 3-[methyl(propan-2-yl)amino]-2-(2-methyl-1H-indol-5-yl)quinoxaline-6-carboxylic acid as a orange solid (500 mg, 78%).

Provenance & Evidence