Ammonium Chloride → HCID 178505541, compound

Participants

Reaction Steps

A solution of 2,3-bis(4-fluorophenyl)quinoxaline-6-carbonitrile (150 mg, 0.44 mmol, 1.00 equiv) in N,N-dimethylformamide (10 mL), NaN3 (500 mg, 7.69 mmol, 17.59 equiv), and NH4Cl (116 mg, 2.19 mmol, 5.00 equiv) was stirred for 4 h at 100° C. in an oil bath. The reaction was then quenched by the addition of water. The resulting solution was extracted with 7×50 mL of dichloromethane and the organic layers combined and dried over anhydrous sodium sulfate. The resulting mixture was concentrated in vacuo, washed with dichloromethane, resulting in 34 mg (20%) of 2,3-bis(4-fluorophenyl)-6-(1H-tetrazol-5-yl)quinoxaline as a white solid.

Provenance & Evidence