Ammonium Chloride → HCID 178435847, compound

Participants

Reaction Steps

A solution of 2,3-bis(4-ethylphenyl)quinoxaline-6-carbonitrile (200 mg, 0.55 mmol, 1.00 equiv) in N,N-dimethylformamide (6 mL), NaN3 (179 mg, 2.75 mmol, 5.00 equiv), and NH4Cl (146 mg, 2.75 mmol, 5.00 equiv) was stirred for 7 h at 100° C. in an oil bath. The reaction was then quenched by the addition of water. The resulting solution was extracted with 8×50 mL of dichloromethane and the organic layers combined and dried over anhydrous sodium sulfate. The resulting solution was concentrated in vacuo, and washed with methanol. This resulted in 98 mg (44%) of 2,3-bis(4-ethylphenyl)-6-(1H-tetrazol-5-yl)quinoxaline as a white solid.

Provenance & Evidence