Tert-Butylamine → HCID 70654277, compound

Participants

Reaction Steps

To a solution of (R)-3-(sec-butyl(methyl)amino)-2-(4-fluorophenyl)quinoxaline-6-carboxylic acid (500 mg, 1.42 mmol) in dichloromethane (30 mL) was added triethylamine (348 mg, 3.44 mmol), 2-methylpropan-2-amine (197 mg, 2.7 mmol), and T3P (12 mL), and the reaction mixture was stirred overnight at room temperature. The resulting solution was diluted with water (150 mL) and extracted with dichloromethane (4×50 mL), the organic layers combined and dried over anhydrous magnesium sulfate and concentrated in vacuo to afford (R)—N-tert-butyl-3-(sec-butyl(methyl)amino)-2-(4-fluorophenyl)quinoxaline-6-carboxamide as a yellow solid (750 mg, crude).

Provenance & Evidence