Hydrochloric Acid → HCID 178456037, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (R)-3-(sec-butyl(methyl)amino)-2-(4-fluorophenyl)quinoxaline-6-carbonitrile (170 mg, 0.51 mmol) in DMSO (25 mL) was added NaN3 (101 mg, 1.55 mmol), ZnBr2 (56 mg, 0.25 mmol) and water (3 mL) and the resulting mixture was stirred overnight at 130° C. The solution was diluted with water (200 mL) and adjusted to pH 4 with HCl (3N), extracted with ethyl acetate (5×50 mL), and the organic layers combined and dried over anhydrous magnesium and concentrated in vacuo to afford (R)—N-sec-butyl-3-(4-fluorophenyl)-N-methyl-7-(1H-tetrazol-5-yl)quinoxalin-2-amine as a yellow solid (72.3 mg, 37%).

Provenance & Evidence