Potassium Hydroxide → HCID 70654212, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 3-[methyl(propan-2-yl)amino]-2-oxo-1,2-dihydroquinoxaline-6-carboxylate (2.5 g, 9.08 mmol) in methanol (20 ml) was added potassium hydroxide (2.5 g, 44.56 mmol) in water (5 ml). The resulting solution was stirred overnight at 50° C. and then concentrated in vacuo. The reaction was quenched water (100 ml). The pH was adjusted to 5 with HCl (3N). The product was precipitated from water and collected by filtration to afford 3-[methyl(propan-2-yl)amino]-2-oxo-1,2-dihydroquinoxaline-6-carboxylic acid as a white solid (2.1 g, 88%).

Provenance & Evidence