Hydrochloric Acid → HCID 70654239, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N-(2,3-bis(4-methoxyphenyl)quinoxalin-6-yl)-N-(methylsulfonyl)methanesulfonamide (143.64 mg, 0.28 mmol, 1.00 equiv, 90%) in tetrahydrofuran/MeOH (1:1, 10 mL) was added LiOH H2O (58.5 mg, 1.39 mmol, 5.00 equiv). This was followed by the dropwise addition of a solution of sodium hydroxide (56 mg, 1.40 mmol, 5.00 equiv) in water (2 mL). The resulting solution was stirred for 1 h at 35° C. in an oil bath. The pH was adjusted to 7-8 with 1N HCl. The resulting mixture was concentrated in vacuo and washed with methanol, resulting in 46.5 mg (37%) of N-(2,3-bis(4-methoxyphenyl)quinoxalin-6-yl)methanesulfonamide as a yellow solid.

Provenance & Evidence