N-BOC-ethylenediamine → HCID 86723055, compound

HRID 1405616Notes

Reaction equation

HRID 1405616 reaction equation
[Cl:1][C:2]1[C:11]2[N:10](C)C(=O)O[C:7](=[O:14])[C:6]=2[CH:5]=[CH:4][CH:3]=1.[C:15]([NH:22][CH2:23][CH2:24][NH2:25])([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16]>>[C:18]([O:17][C:15](=[O:16])[NH:22][CH2:23][CH2:24][NH:25][C:7](=[O:14])[C:6]1[CH:5]=[CH:4][CH:3]=[C:2]([Cl:1])[C:11]=1[NH2:10])([CH3:21])([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 187201N-BOC-ethylenediamineHCID 18803579HCID 18803579, compound

Product 1

HCID 86723055HCID 86723055, compoundYield 84%

Procedure

Starting from 8-chloro-1-methyl-2H-3,1-benzoxazine-2,4(1H)-dione and N-Boc-ethylenediamine and using Procedure S, the title intermediate was obtained as a colourless solid (264 mg; 84% yield).

Sources & evidence

ORD record
ord-a14209b7a6fb40229c5941608e37ba78
Source dataset
uspto-grants-2014_12
Patent number
US08916573B2

Reaction notes

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