6-Methylanthranilic acid → 2-amino-6-methyl-N-{3-[(R)-2-oxo-3-(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-yl)-oxazolidin-5-yl]-propyl}-benzamide

Participants

Role	Name	HCID	Charge
Reactant	6-Methylanthranilic acid	HCID 151210	—
Reactant	6-[(R)-5-(3-amino-propyl)-2-oxo-oxazolidin-3-yl]-4H-benzo[1,4]thiazin-3-one	HCID 67303587	—
Product	2-amino-6-methyl-N-{3-[(R)-2-oxo-3-(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-yl)-oxazolidin-5-yl]-propyl}-benzamide	HCID 86723057	77%

Reaction Steps

Starting from 2-amino-6-methylbenzoic acid and 6-[(R)-5-(3-amino-propyl)-2-oxo-oxazolidin-3-yl]-4H-benzo[1,4]thiazin-3-one (described in WO 2010/041219) and using Procedure D, the title compound was obtained as a beige solid (180 mg; 77% yield).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08916573B2
Source dataset	uspto-grants-2014_12
ORD ID	ord-1a0561690260494f9d6d436794a07fbf
Source note	uspto-grants-2014_12