HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-methylbenzoic acid → 2-amino-5-methyl-N-{3-[(R)-2-oxo-3-(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-yl)-oxazolidin-5-yl]-propyl}-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-methylbenzoic acid | HCID 76255 | — |
| Reactant | 6-[(R)-5-(3-amino-propyl)-2-oxo-oxazolidin-3-yl]-4H-benzo[1,4]thiazin-3-one | HCID 67303587 | — |
| Product | 2-amino-5-methyl-N-{3-[(R)-2-oxo-3-(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-yl)-oxazolidin-5-yl]-propyl}-benzamide | HCID 86723058 | 56% |
Reaction Steps
Starting from 2-amino-5-methylbenzoic acid and 6-[(R)-5-(3-amino-propyl)-2-oxo-oxazolidin-3-yl]-4H-benzo[1,4]thiazin-3-one (described in WO 2010/041219) and using Procedure D, the title compound was obtained as a beige solid (130 mg; 56% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916573B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-48e0e54ea24543bcb26c74ff7be31e8f |
| Source note | uspto-grants-2014_12 |