HCID 10035843, compound → HCID 71255599, compound

HRID 1405638Notes

Reaction equation

HRID 1405638 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]1[C:13](=[O:14])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][C:5]1=[O:15].I[CH2:17][C@H:18]1[O:22][C:21](=[O:23])[N:20]([C:24]2[CH:25]=[CH:26][C:27]3[S:32][CH2:31][C:30](=[O:33])[NH:29][C:28]=3[CH:34]=2)[CH2:19]1>>[O:23]=[C:21]1[N:20]([C:24]2[CH:25]=[CH:26][C:27]3[S:32][CH2:31][C:30](=[O:33])[NH:29][C:28]=3[CH:34]=2)[CH2:19][C@@H:18]([CH2:17][NH:1][CH2:2][CH2:3][N:4]2[C:13](=[O:14])[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[NH:6][C:5]2=[O:15])[O:22]1

Participants

3

Reactant 2

HCID 10035843HCID 10035843, compoundHCID 66751595HCID 66751595, compound

Product 1

HCID 71255599HCID 71255599, compoundYield 19%

Procedure

Starting from 3-(2-aminoethyl)-2,4(1H,3H)-quinazolinedione (prepared according to J. Med. Chem. (1992), 35(26), 4903-10) and 6-((S)-5-iodomethyl-2-oxooxazolidin-3-yl)-4H-benzo[1,4]thiazin-3-one (prepared according to WO 2008/126034) and using Procedure F, the title compound was obtained as a yellow solid (23 mg; 19% yield).

Sources & evidence

ORD record
ord-581d1fe35b4b4185953579a0c740f2c9
Source dataset
uspto-grants-2014_12
Patent number
US08916573B2

Reaction notes

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