Methanol → HCID 53663529, compound

HRID 1405942Notes

Reaction equation

HRID 1405942 reaction equation
C([O:8][C:9]([NH:11][CH2:12][CH2:13][S:14]([NH2:17])(=[O:16])=[O:15])=O)C1C=CC=CC=1.CO>[Pd].C(O)=O>[CH:9]([NH:11][CH2:12][CH2:13][S:14]([NH2:17])(=[O:16])=[O:15])=[O:8]

Participants

5

Reactant 2

HCID 887MethanolHCID 11615848Phenylmethyl N-[2-(aminosulfonyl)ethyl]carbamate

Product 1

HCID 53663529HCID 53663529, compoundYield 93%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 284Formic AcidSolvent

Procedure

In a reaction flask, 10.3 g of 2-benzyloxyformamidoethylsulfonamide, 10% Pd/C (3.0 g) and 600 ml of methanol were added. The mixture was stirred at room temperature overnight under hydrogen atmosphere, added with 35 ml of formic acid, stirred for 30 min, filtered, and concentrated under a reduced pressure to obtain 5.6 g of oily product, yield 93%.

Workup

  1. stirringstirred for 30 min
  2. filtrationfiltered
  3. concentrationconcentrated under a reduced pressure

Sources & evidence

ORD record
ord-295e840ebcbc4de99c2ded232ca6a24d
Source dataset
uspto-grants-2014_12
Patent number
US08916574B2

Reaction notes

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