Methylhydrazine → HCID 68295431, compound

HRID 1406001Notes

Reaction equation

HRID 1406001 reaction equation
C[O:2][C:3]1(OC)[CH2:9][CH2:8][CH2:7][CH2:6][CH:5]([C:10](=O)[C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:4]1=O.[CH3:20][NH:21][NH2:22]>CCO.CC(O)=O>[CH3:20][N:21]1[C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:3](=[O:2])[C:4]2=[N:22]1

Participants

5

Reactant 2

HCID 6061MethylhydrazineHCID 68358222HCID 68358222, compound

Product 1

HCID 68295431HCID 68295431, compoundYield 379.8%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 702EthanolSolvent

Procedure

To a solution of ethyl (3,3-dimethoxy-2-oxocycloheptyl)(oxo)acetate 0.090 g (0.33 mmol) in 2 mL of EtOH and 4 mL of AcOH, 0.020 mL (0.039 mmol) of N-methylhydrazine was added. The mixture was stirred overnight at room temperature. The solvent was removed under reduced pressure and the crude solid was purified by flash chromatography on silica gel (eluant: AcOEt/hexane 8/2) to afford 0.035 g (38% yield) of the title compound as colorless oil.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude solid was purified by flash chromatography on silica gel (eluant: AcOEt/hexane 8/2)

Sources & evidence

ORD record
ord-7b1f4e81fddd4b23997314bb4d5c0e39
Source dataset
uspto-grants-2014_12
Patent number
US08916577B2

Reaction notes

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