反应详情

To a solution of ethyl (3,3-dimethoxy-2-oxocycloheptyl)(oxo)acetate 0.090 g (0.33 mmol) in 2 mL of EtOH and 4 mL of AcOH, 0.020 mL (0.039 mmol) of N-methylhydrazine was added. The mixture was stirred overnight at room temperature. The solvent was removed under reduced pressure and the crude solid was purified by flash chromatography on silica gel (eluant: AcOEt/hexane 8/2) to afford 0.035 g (38% yield) of the title compound as colorless oil.

1. customThe solvent was removed under reduced pressure
2. customthe crude solid was purified by flash chromatography on silica gel (eluant: AcOEt/hexane 8/2)