Carbonic acid-guanidine (1:1) → HCID 68294996, compound

HRID 1406010Notes

Reaction equation

HRID 1406010 reaction equation
CN(/[CH:4]=[C:5]1\[CH2:6][CH2:7][CH2:8][C:9]2[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[N:12][N:11]([CH3:19])[C:10]=2[C:20]\1=O)C.C(=O)(O)O.[NH2:26][C:27]([NH2:29])=[NH:28]>CCO>[NH2:28][C:27]1[N:29]=[C:20]2[C:10]3[N:11]([CH3:19])[N:12]=[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:9]=3[CH2:8][CH2:7][CH2:6][C:5]2=[CH:4][N:26]=1

Participants

4

Reactant 2

HCID 286947Carbonic acid-guanidine (1:1)HCID 68358107HCID 68358107, compound

Product 1

HCID 68294996HCID 68294996, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of ethyl (7E)-7-[(dimethylamino)methylidene]-1-methyl-8-oxo-1,4,5,6,7,8-hexahydrocyclohepta[c]pyrazole-3-carboxylate (240 mg, 0.86 mmol) in EtOH (7.5 mL), guanidine carbonate (86 mg, 0.47 mmol) was added. The reaction mixture was stirred under reflux for 24 h. The solvent was removed under reduced pressure, the crude was triturated with hexane and EtOH and collected by filtration to give 84 mg of a white solid (79% yield).

Workup

  1. temperatureunder reflux for 24 h
  2. customThe solvent was removed under reduced pressure
  3. customthe crude was triturated with hexane and EtOH
  4. filtrationcollected by filtration

Sources & evidence

ORD record
ord-75bcb8c1414d435cb4f1185cb0ab0c84
Source dataset
uspto-grants-2014_12
Patent number
US08916577B2

Reaction notes

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