Ethyl Bromide → HCID 60151777, compound

Participants

Reaction Steps

To a solution of N-(2,6-diethylphenyl)-9-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}-1,4,5,6-tetrahydropyrazolo[4′,3′:6,7]cyclohepta[1,2-d]pyrimidine-3-carboxamide (0.065 g, 0.11 mmol) in DMF (1.1 mL), Cs2CO3 (0.073 g, 0.22 mmol) and bromoethane (0.008 mL, 0.11 mmol) were added. The mixture was stirred at room temperature for 12 h, solvent was removed under vacuo, then DCM (10 mL) was added and the organic phase washed with water (2×15 mL). The organic fraction was, dried over Na2SO4, filtered, and concentrated in vacuo. Purification by flash chromatography on silica gel (eluant: DCM/MeOH95/5) provided 30 mg (30%) of the title compound as a pale yellow solid.

Provenance & Evidence