Sodium Hydroxide → HCID 68358254, compound

Participants

Reaction Steps

Ethyl 9-[(4-bromo-2-methoxyphenyl)amino]-2-methyl-2,4,5,6-tetrahydropyrazolo[4′,3′:6,7]cyclohepta[1,2-d]pyrimidine-3-carboxylate (0.250 g, 0.530 mmol) was suspended in anhydrous EtOH (5 mL) and treated with a 2 M solution of NaOH (0.260 mL, 0.5 eq.) at reflux temperature for 1 hour. Solvent was evaporated to dryness and the residue dissolved in water. After treatment with AcOH, the resulting precipitate was collected by filtration to give the title compound (190 mg, 80% yield) as a white solid.

Provenance & Evidence