Sodium Iodide → HCID 178502687, compound

Participants

Reaction Steps

To a solution of N,9-dimethoxy-N,1-dimethyl-1,4,5,6-tetrahydropyrazolo[4′,3′:6,7]cyclohepta[1,2-d]pyrimidine-3-carboxamide (583 mg, 1.8 mmol) in CH3CN (35 mL), sodium iodide (550 mg, 3.67 mmol) and trimethylsilylchloride (0.525 mL, 4.14 mmol) were added in sequence. Mixture was stirred for 24 h under argon atmosphere at room temperature then a second portion of sodium iodide (275 mg, 1.8 mmol) and trimethylsilylchloride (0.276 mL, 2.1 mmol) were added in sequence. After 24 h the solvent was evaporated, the residue dissolved with a mixture of DCM/MeOH (4/1) and washed with a saturated aqueous solution of Na2S2O3. The organic layer was dried over Na2SO4. The residue was crystallized from MeOH to give 452 mg (83% yield) of a white solid.

Provenance & Evidence