1-Methylpiperazine → HCID 60152865, compound

Participants

Reaction Conditions

Reaction Steps

Pd2(dba)3, (0.002 g, 0.002 mmol), 2-dicyclohexylphosphino-2′-(N,N-dimethylamino)-biphenyl (0.002 g, 0.005 mmol), 9-[(4-bromo-2-methoxyphenyl)amino]-N-(2-ethylphenyl)-1-methyl-1,4,5,6-tetrahydropyrazolo[4′,3′:6,7]cyclohepta[1,2-d]pyrimidine-3-carboxamide (0.040 g, 0.07 mmol) in THF (1 mL) were charged in a round-bottomed flask flushed with argon. The flask was evacuated and backfilled with argon. LiN(TMS)2 solution (1M in THF, 0.9 mL) and N-methylpiperazine (0.030 mL, 0.30 mmol) were added and the reaction mixture was heated at 85° C. for 0.5 h. The reaction mixture was then allowed to cool to room temperature and concentrated. The crude solid was purified by flash chromatography on silica gel (eluant: DCM/MeOH 95/5) to afford 0.040 g (95% yield) of the title compound as yellow solid.

Provenance & Evidence