Cesium carbonate → HCID 68295583, compound

Participants

Reaction Steps

To a solution of 9-amino-N-(2,6-diethylphenyl)-1-methyl-1,4,5,6-tetrahydropyrazolo[4′,3′:6,7]cyclohepta[1,2-d]pyrimidine-3-carboxamide (0.375 mg, 0.96 mmol) in dioxane (10 mL), tert-butyl 4-iodo-3-methoxybenzoate (0.320 mg, 0.96 mmol) and Cs2CO3 (0.470 g, 1.44 mmol) were added and the flask was evacuated and backfilled with argon. Pd2(dba)3 (0.088 g, 0.096 mmol) and Xantphos (0.110 g, 0.192 mmol) were then charged and the mixture was refluxed under argon for 4 h. After cooling to room temperature, the reaction mixture was concentrated, suspended in water (50 mL) and extracted with AcOEt. The organic phase was anidrified on Na2SO4, filtered and evaporated to dryness, the crude solid was purified by flash chromatography on silica gel (eluant: hexane/AcOEt 8/2) to afford 0.480 g (84% yield) of the title compound.

Provenance & Evidence