4-Bromothiophenol → HCID 86701842, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-[methoxy(methyl)carbamoyl]-1-methyl-1,4,5,6-tetrahydropyrazolo[4′,3′:6,7]cyclohepta[1,2-d]pyrimidin-9-yl trifluoromethanesulfonate (70 mg, 0.16 mmol) in THF (3 mL), 4-bromothiophenol was added in microwave vial flushed under argon. The reaction mixture was stirred at 60° C. for 48 h. The solvent was removed under reduced pressure, the crude was purified by preparative HPLC to give 2 mg (2% yield) of the title compound.

Provenance & Evidence