Potassium Carbonate → HCID 86701844, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of Pd(OAc)2 (2 mg, 0.009 mmol), Xantphos (11 mg, 0.019 mmol), 3-[methoxy(methyl)carbamoyl]-1-methyl-1,4,5,6-tetrahydropyrazolo[4′,3′:6,7]cyclohepta[1,2-d]pyrimidin-9-yl trifluoromethanesulfonate (40 mg, 0.09 mmol), K2CO3 (248 mg, 1.8 mmol), 4-Morpholin-4-yl-phenylamine (21 mg, 0.12 mmol) in dioxane (3 mL) were charged in a round-bottom flask flushed with argon. The flask was evacuated and backfilled with argon and the reaction mixture was heated at 80° C. for 48 h. The reaction mixture was then allowed to cool to room temperature and concentrated. The crude solid was purified by RP flash chromatography to afford 13 mg (30% yield) of the title compound.

Provenance & Evidence