p-Toluenesulfonic acid → HCID 68358266, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 2-(2-hydroxyethyl)-9-(methylsulfanyl)-2,4,5,6-tetrahydropyrazolo[4′,3′:6,7]cyclohepta[1,2-d]pyrimidine-3-carboxylate 34.8 mg (0.1 mmol) in THF (3 ml) was added p-toluensulfonic acid 1.9 mg (0.01 mmol). The mixture was stirred at 60° C. for 4 hours. Upon completion, the volatiles were removed in vacuo, the residue was purified by flash chromatography eluting with EtOAc/hexane 5/5 to afford 15 mg of the title compound (50% yield).

Provenance & Evidence