HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Formylfuran-2-boronic acid → 1-Bromo-4-(pentafluoroethyl)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Formylfuran-2-boronic acid | HCID 2734355 | — |
| Reactant | 1-Bromo-4-(pentafluoroethyl)benzene | HCID 54209708 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 1-Bromo-4-(pentafluoroethyl)benzene | HCID 54209708 | — |
| Product | {cis-5-[4-(Pentafluoroethyl)phenyl]tetrahydrofuran-2-yl}methanol | HCID 86713729 | — |
Reaction Steps
The requisite {cis-5-[4-(pentafluoroethyl)phenyl]tetrahydrofuran-2-yl}methanol was prepared via Suzuki reaction of (5-formylfuran-2-yl)boronic acid with 1-bromo-4-(pentafluoroethyl)benzene, followed by hydrogenation over palladium on carbon. 1-Bromo-4-(pentafluoroethyl)benzene was prepared according to the method of W. Lambert et al., PCT Int. Appl., 2011017513, Feb. 10, 2011.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916564B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-2fe7a4fa437648d3a4ee733db2e82543 |
| Source note | uspto-grants-2014_12 |