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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1406063Generated: October 31, 2026

5-Bromofuran-2-carbaldehyde → HCID 86713730, compound

https://huagongshe.com/reaction/1406063

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Bromofuran-2-carbaldehydeHCID 600328—
Reactant2-[4-(1,1-Difluoroethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneHCID 46835487—
CatalystRuthenium dioxide hydrateHCID 16211523—
ProductHCID 86713730HCID 86713730—

Reaction Steps

The requisite {cis-5-[4-(1,1-difluoroethyl)phenyl]tetrahydrofuran-2-yl}methanol was prepared via Suzuki reaction of 5-bromofuran-2-carbaldehyde with 2-[4-(1,1-difluoroethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, followed by hydrogenation in the presence of ruthenium(IV) oxide hydrate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08916564B2
Source datasetuspto-grants-2014_12
ORD IDord-728dc14100d34d39adbcd8539b0697fe
Source noteuspto-grants-2014_12