HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-4-hydroxy-7-isopropoxy-isoquinoline-3-carboxylic acid → (R)-2-[(1-Chloro-4-hydroxy-7-isopropoxy-isoquinoline-3-carbonyl)-amino]-3-hydroxy-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-4-hydroxy-7-isopropoxy-isoquinoline-3-carboxylic acid | HCID 53870439 | — |
| Reactant | H-D-Ser(tBu)-OtBu.HCl | HCID 56777372 | — |
| Product | (R)-2-[(1-Chloro-4-hydroxy-7-isopropoxy-isoquinoline-3-carbonyl)-amino]-3-hydroxy-propionic acid | HCID 86595452 | — |
Reaction Steps
Prepared in analogy to Example A-2 e) and f) from 1-chloro-4-hydroxy-7-isopropoxy-isoquinoline-3-carboxylic acid (can be obtained according to U.S. Pat. No. 6,093,730, 10/1998, Weidmann et al.) and (R)-2-amino-3-tert-butoxy-propionic acid tert-butyl ester hydrochloride; MS-(+)-ion: M+1=369.0 amu.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916585B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-e7b5f3b7808641cdb02fb398c17a07af |
| Source note | uspto-grants-2014_12 |